Thursday, April 29, 2010

Cut By Hairdresser Bleed Ear Hiv

Ganadla by our captain Stephen

remain four days to complete the league and the championship is more open than ever. The FC Barcelona is losing to Inter in the Champions League semifinals on Saturday and has a complicated grief in the area of \u200b\u200bVillarreal, a team that historically has never done well at Barça. For its part, hosts Osasuna Real Madrid, who hardly plays anything, as comfortable mid-table browsing. The Madrid fans know that this may be the key weekend of the season. The leader is wounded, defeat against the Italians (and Mourinho) was a stick, both physically and psychologically . Guardiola has a recovery job ahead between now and Saturday, should take it forward, show what a great coach he is.

Of the other three games, each team has no choice difficult. visit Madrid and Barca Mallorca, Sevilla. The two teams play Champions League and will enter all the meat on the grill to get the win . In addition, the Madrid welcomes Athletic and visit Malaga, while Barcelona has to play at home to Tenerife and Valladolid, teams that occupy space relegation to the Second. In principle, Real Madrid's calendar seems more affordable, hence both the club and its media environment make use of the famous plot of 98 points to win the league. If the club sum 99, there will be only congratulate them.

Madrid has reason to believe. It's a team with courage. He has shown this year, rising from the many blows he has received throughout the season (Alcorcón, Lyon and defeats against Barcelona) and there is, at one point the best team in the world. also has shown throughout its history, without going further three years ago, when the team coached by Fabio Capello got a win in League unfit for heart disease, based on impossible comebacks. The clearest example, those thirteen seconds in which magical goals from Van Nistelrooy and Tamudo put the lead at Real Madrid in the penultimate round.



Throughout the year, Madrid is living in the shadow of Barcelona. The humiliation of Alcorcón in October was the subject of scorn and derision. Guardiola's team marveled at his game, while Pellegrini, questioned all along, seemed to find the promised excellence in summer. March came and Olympique Lyon set eliminated the white of the Champions League final which is played in the sanctuary Madrid. Recovery the lead in the League served as a balm to the defeat at home to arch-rivals 0-2. Once you know that Barca will miss the Champions League final, it's time to strike a blow on the table and change the order in the hierarchy of English football . The comeback is possible.

This comeback may not participate our captain. Raul was injured on Saturday in La Romareda and will not play in any of the four days remaining for the final. This must be another reason for the title. Raul forced his body to help the team, left the skin in Zaragoza and left the field injured shortly after scoring the first goal for his team. A again served as a perfect example for both their peers and for future generations. This league has to be earned by Madrid. Must be won by Raúl . Reading

Tuesday, April 27, 2010

Name Of Current La Senza Model

Top! President

holder assumes that I will make a plea for one of the social phenomena of modern English history: Belén Esteban. But neither am your friend, and his television appearances produce me other than feeling empathy, to play the role of a woman who, in his day, was undermined by a family of powerful , to which, over time, is giving a lesson on how to capitalize on the damage he did in the past.

Belén Esteban became famous for maintaining a relationship with the bullfighter Jesulín Ubrique and having a daughter with him. As I said before, the political family she never accepted it and decided to defend where better paid, in a television studio. I guess like others and others, won a lot of money. Everyone thought that the Esteban had his moment of glory and become one of many famous ex would quickly memory lane. But ten years later, there is. Stronger than ever. In 1998, Jesulín was a famous bullfighter and her partner. In 2010, I dare say she is the personality and he has long ago ceased to be news for bulls triumphs.

If something is missing from Bethlehem are detractors. His enemies did not explain how a girl like her neighborhood, uneducated and without posing a perfect paradigm of education, can succeed in today's television. Belén Esteban triumphs as just that. She is the type of woman in the neighborhood who has managed to overcome a life clubs. His life has been a soap opera, always planning between happiness and tragedy. And all this televised or printed in the gossip magazines . His leap to Telecinco channel unscrupulous excellence, gave the final push to the character. First in the Ana Rosa program (which probably came because Bethlehem was more popular than the host itself) and then in different Save me. The Princess of San Blas has soared in popularity to win the affection of the common people. The figures speak for themselves: their programs clean sweep of hearing, the day of his comeback after undergoing surgery program made a 26% share (seven points above the average of the chain) and the stroke that presented with Jorge Javier Vázquez audience broke the historical record in a private channel. In addition, his name was the second term which experienced a greater increase worldwide in Google with a 1350% increase during the week of 15 to 21 December 2009 (the comeback).

And what makes a journalist is supposed to defend it if he's stealing the job? This seems to me the biggest lie of all phenomenon Esteban. Bethlehem do not think he is taking our jobs to anyone, she is dedicated to reprise his role, which makes it perfect. has what he wants from his private life and continues to maintain its private war against the family Janeiro, in what seems an endless soap opera . She's not a journalist, does not serve as such. And I do not work every journalist dreams since childhood is to have his life in a program, set up some show and discuss Big Brother or Survivor. If so, go bad. Belén Esteban spent ten years earning a living honestly, as we would anyone in their situation. O critics who prefer to work twelve hours cleaning homes for a minimum wage to do it on TV for a bundle .

Maybe the blame belongs to those who paid the dough roll and allows you to appear as many hours in the TV programming. We see the TV guide and full of heart programs at all times, each with its imitation of Belén Esteban. However, it was has taken advantage of better chance. And it will doing when you leave. Silly if you do what otherwise would .

Thursday, April 22, 2010

Where To Buy Vintage Stereo Receivers

forever ... Rafa out of the tunnel

has died Juan Antonio Samaranch. Pope has left us of Sport. I read this name to Alfredo Relaño, editor of AS, a few days ago. And in that moment, I came to my mind the image of John Paul II. The two (Samaranch and Wojtyla) I conveyed the same picture: venerable and wise old men whom the world has much to be thankful and a kind of halo around the closer, at least for me, mythological figures.


was born
in 1985. My earliest sports memories are of 1992 Barcelona Olympics. But Samaranch, these Olympics would not have been possible . And who knows? Maybe today would be operating patients, doing audits, or mixing cement on site. Those games, like all my generation, I was struck by: Freddy Mercury and Montserrat Caballé in the opening ceremony, the Hello, who welcomed the world, tears of Samaranch and the King, the "Friends Forever" of Los Manolos, the glorious triumph of Fermin Cacho in the final 1,500 meters, with the entire arena cheering at full stretch, the goals of Kiko, gold Lopez Zubero claw Arantxa, judo, water polo, the Dream Team ...



Juan Antonio loved his city and country. In 1992, Spain was no longer a Third World country (athletically speaking) to sit on the elite Olympic panorama. The golden age that we live today (football, basketball, tennis, cycling and many other sports aces), born and raised under the influence of Barcelona 92. Moreover, politically we are open to the world, who could see that the dictatorship was over. But this was not the only merit of Samaranch. He fought for his country, but above all, fought for the Olympics, the sport.

The world came from two world wars that had divided the globe into two parts. Sports, the Olympics were more politicized than ever. Samaranch brought down that wall. Universalized the Games, leading even to Oceania. His latest conquest was the communist dictatorship cerradísima China: Beijing 2008 . Such is the impression it left in its wake the president of the IOC, that even the Chinese have felt his death.

Another task performed to perfection by Samaranch was the professionalization of the Games. Over time, the great athletes had lost interest in winning Olympic medals. During his tenure, Samaranch returned to the Games fame and honor in ancient Greece had . His first great triumph was to make the big stars of the NBA went to the appointment. His latest success in this section, attitudes like Rafa Nadal in Beijing, where he enjoyed the Olympic experience as an athlete more. If the cracks were erased before the appointment, now regret not being able to participate. I come to mind words of Iker Casillas, captain of the English football team, who said a few years ago I had the thorn stuck had not been enjoying the Olympics.

But it was not all joy during his years in office (both real and honorary). The Salt Lake City scandal cost him much trouble, but pulled through. A weak entity would have collapsed before these events, but the IOC, Samaranch was built to replace the bump knew. But his biggest disappointment gave it a few months ago.

Exerting prophet, Juan Antonio asked one last favor to his colleagues on the committee: the Games to Madrid in 2016. The request fell on deaf ears and gave the Games to Rio de Janeiro. However, Madrid will not surrender and the fact that the Games for the first time traveling to South America is another sign of globalization initiated by Samaranch in 1980. The sport will miss him. London, Rio de Janeiro and the following Olympic events will honor. The Olympic flame has diminished since his death, but thanks to people like him never be extinguished. Rest in Pau, Joan Antoni .

Tuesday, April 20, 2010

Pokemon Emerald Infinate Money



May 4, 2009. Rafael Nadal defeated in the final of the Rome Masters 1000 to Novak Djokovic 7-6, 6-2. Comes to string three consecutive titles (Monte Carlo, Barcelona and Rome), besides having won earlier this year Australia's Open and the first position in the ATP rankings. Before him is the challenge of winning Roland Garros for the sixth straight year. His opponents fear him and there is talk of a new dominating the tennis world. The great Roger Federer may go down in history.



April 18, 2010. Nadal returns to win an individual title for almost a year after their last trophy. He does it in Monte Carlo, where wins for the sixth time, sweeping all his rivals, including his friend Fernando Verdasco, who at the very end, is only able to win a game of Manacor (6-0 6-1). between, Rafa living a nightmare of injuries and lost the first position ranking. His "enemy" Federer, rises from the ashes and triumphs at Roland Garros and Wimbledon, recovering scepter of world tennis. Nadal has to hear all sorts of criticism, if his way of playing tennis is going to take an early withdrawal, if you can not give more of himself, that if young people coming behind you will pass on the ranking, ...

First, coldly analyze the results obtained by Nadal this year in which, remember, had to stop several times because of injuries: Davis Cup champion, three finals (Madrid, Shanghai and Doha) , a semifinalist in U.S. Open, Cincinnati, Beijing, Paris, Indian Wells and Miami, and quarterfinalist at the Open de Australia. just disappointed in Roland Garros (4 th round) and on the ATP Tour World Finals (Round Robin ) . All this, including downtime and laps because of his battered knees. And, according to experts, more than one loss came as a result of lack of confidence logic that produced their physical discomfort. For years, we've all thought that Rafa is a time machine and has shown us that it is not. Nadal is human. Perhaps a little less human than the ordinary citizen, but his body, like the rest, you can go through these cycles of injury. The important thing is that their mentality Winning is doing back on the road to success.

The first setback came at home in Madrid, where he defeated Roger Federer in the final with a double 6-4. Rafa reached the final after he defeated Djokovic in the semifinals 7-6 7-6 3-6 after more than four hours of play. No alarm bells ringing. The defeat came at Roland Garros after breaking Bjorn Borg's streak of wins in a row in the French courts. Nadal made it 31 matches. Here we would set off alarm bells, because Rafa began to show signs of fatigue. But the bomb exploded a few weeks later, Nadal announced a temporary withdrawal of the circuit to undergo treatment on his knees, to defend the title at Wimbledon . This meant the loss of world number one. In addition, it also issued the separation of their parents, which was a personal blow to the Spaniard.

returned to the track in Montreal, two and a half months after his last tournament. There he fell in the quarterfinals and lost to Del Potro's second ranking position. The criticism began to fall on you, but Rafa responded with great maturity, if not number one, he did not care are the two, three or four. He wanted to recover. Cincinnati recovered feelings towards the last Grand Slam of year, but Djokovic him out of the finals, proving that Nadal's fitness was not optimal to deal with their biggest rivals.

At the U.S. Open again pulling claw to stand in the semifinals. There was swept away by Juan Martin del Potro, eventual champion, by a 6-2 triple. Until the end of the season, Rafa continued recovering feelings, but could not defeat top level players . Was missing a step, perhaps confidence, in order to become the one before. In the last months of the year lost to Cilic Davydenko (twice), Djokovic (also twice) and Soderling. Especially painful was his participation in the World Finals, losing all three games without being able to win a set. With this background, Nadal was planted in the Davis Cup final with the need to close the year with a win. And he did. won his two singles matches and Spain won its fourth Salad . Thus, Nadal closed 2009 with a smile and in order to rebuild trust.

And that trust is slowly recovering. The beginning of the year was promising, with finish in the prestigious tournament in Doha, losing to Davydenko after having won the match. However, Australia will again invade the doubts in his quarter- final against Andy Murray. Rafa withdrew in the third set after noticing now, again, on his knees. Becomes a concern in the environment player. Nadal decides to rest for two months until the U.S. tour, where he does both in Indian Wells semifinals and Miami.

Then came the ground. Nadal territory. In Monte Carlo walks Rafa winning all their matches easily. The data is overwhelming: only lost twelve games in the tournament. Your ride, both in semis against Ferrer (6-2 6-3) and in the final against Verdasco (6-0 6-1), shows that Nadal has become the best. Has regained confidence in itself. Furthermore, in a sign of his maturity, the Spaniard decides to give to participate in the tournament in Barcelona, \u200b\u200bhis club, to take care of physically. For the first time in years, Rafa acts with the head and not your heart. The experience of recent months has been learned. Now, Rafa has seen the light at the end of the tunnel. The champion is back to stay .

Monday, April 19, 2010

V I D E O S P O R N O S

the whore of Babylon



"whore, the simoniacal, the Inquisitor, torture, counterfeiting, murder, ugly, the mad, bad, and the Holy Office and the Index of Forbidden Books, the Crusader and the night of St. Bartholomew, which sacked Constantinople and Jerusalem bloodshed, which exterminated the Albigenses and the twenty thousand inhabitants of Beziers, which devastated the indigenous cultures of America, which burned Segarelli in Parma, John Hus in Constance and in Rome Giordano Bruno, the opponent of the science, the enemy of truth, the adulterous woman in history, the persecutor of the Jews, the prick of bonfires, the burner of heretics and witches, the swindler of widows, the huntress of inheritance, selling of indulgences, which invented Cristoloco Pedropiedra the rabid and the stupid, the dull promises the kingdom of heaven and threatens eternal fire of hell, the word gagging and shackle the freedom of the soul, while repressing other religions where orders and demands freedom of worship which does not command, he has never loved animals and had compassion on them, the obscurantist, the deceiver, the trickster, the slanderous, the libelous, the repressed, the repressor, La Mirona, the spook, the stubborn, the relapse, the corrupt, hypocritical, the parasite, the drone of anti-Semitism, slavery, the homophobic, the misogynist, the carnivorous, the butcher, the beggar, the truffle, the liar, the insidious, the traitor , the dispossessed, the thief, the manipulative, the predatory, the oppressor, the treacherous, the fallacious, the raptor, the felony, the aberrant, the inconsequential, the incoherent, absurd, and the idiotic, the fools, the fool, the stupid, the transvestite, the scarecrow, the queer, the Autocratic, the despotic, tyrannical, the Catholic, Apostolic, Roman, the Jesuit, Dominica, the Opus Dei, the concubine Constantine, Justinian, Charlemagne, the overlapping of Mussolini and Hitler, the whore of harlots, the whore of the harlots, the whore of Babylon, the unpunished bimilenaria have outstanding accounts with me since my childhood and here I shall receivable. "Fernando Vallejo. The Whore of Babylon (Seix Barral, 2009),

Thursday, April 15, 2010

Telescope In Bourne Ultimatum

journalist

The evolution of the Internet in recent years, from Web 1.0 to 3.0, has also meant a change in journalism. To deny this is to live in the past (and this is precisely the problem of some traditional media, to try any digital journalism.) Like all developments, this has its positive aspects and some negative, even for the same journalist .

Thanks to electronic media, blogs and social networks, the user has become an active part of the communication process. Although it sounds strange, we could say that the city has become a journalist (hence the name of citizen journalism, with which is also known to Journalism 3.0 ). This has its advantages because it is a greater connection between the user and the media, for example. Even the reader can participate in the information offered on the net, giving his opinion or correcting any possible error. Finally, the user can also give your own information. On the Web, anyone can publish their own blog or website. In journalism, the roles of transmitter and receiver are blurred, anyone can give any information and can be read (while the traditional media is very clear who issued the information, the newspaper and the recipient, the reader). This aspect, which could be detrimental to the journalist, because you can see "attacked" in their work, should be used to achieve the best possible end: maintaining interactivity with users.

The main objective journalists should seize the opportunities offered by Web 3.0 to better journalism. First, exploitation Social networks can be a very interesting weapon because they are a point of meeting and debate interesting (if used properly.) In addition, the site offers the proximity and upgradeability needed to be able to discuss a live issue, as is happening (a football game, a political debate, a terrorist attack ,...). Over time, stay away from the traditional work of the journalist (covering the story and write in the newspaper) and go to work where the journalist goes on to find the news and can write site or from home .

In conclusion, I would like to stay with positive feature: the multitude of progress that offers Web 3.0 as part of a new journalism. But I think in this new journalism, the reporter must develop a very important task that I have not spoken: educate users so that the benefits do not end up becoming drawbacks. And for that to happen, digital journalist should do their work perfectly, because if we are the first to pervert the new journalism, I can not even imagine what they will do the rest.

Tuesday, April 13, 2010

Peroxide Bleach The Face

3.0 Internet Evolution: from 1.0 to 3.0

before 2.0 or 3.0, we need not be quite ready to conclude that there was a web 1.0. This was known to static pages in html programmed were not updated frequently. The first change came with the success of the dotcom (sometimes called Web 1.5).

The term Web 2.0 was coined in 2004 at a conference by Tim O'Reilly, and is commonly associated with a social phenomenon based on the interaction that is obtained from various web applications that facilitate information sharing, user-centered design and collaboration between them on the network. Examples of Web 2.0 are social networks (Facebook, Twitter, Tuenti ,...), blogs, Flickr, YouTube, Napster, BitTorrent, Google AdSense, Wikipedia or the possibility that the user participate in the formation of the web .

The Web 2.0 is the representation of the evolution of traditional applications to web applications targeted to the user. It is a stage that has defined new projects on the Internet and is concerned to provide best solutions for the end user. Many claim that has reinvented the Internet, others talk of bubbles and investment, but the reality is that the natural evolution of the medium really has proposed the most interesting things existed.

The same trend continuous Internet and makes it talk to other changes, the Web 3.0 . The term first appeared in 2006 in an article by Jeffrey Zeldman, and is used to promote the improvements to the Web 2.0 . There is currently a debate about what Web 3.0 means , and what would be your definition correct. The main innovations of Web 3.0 would include: development of databases, artificial intelligence, Semantic Web and, finally, the evolution to 3D .

The first step towards Web 3.0 is the birth of the Web Data , since the formats in which information is published on the internet are mixed. The recent growth of technology SPARQL allows a standardized language and a better interface for searching through databases network. Thus, the Web Data makes the data as accessible and linkable as Web pages. This is the first step towards the full Semantic Web, which will continue talking later. In this phase, the goal is to make structured data as accessible as possible for the user.

The Web 3.0 has also been used to describe the evolutionary path of the network that leads to artificial intelligence. Sceptics see it as an unattainable vision. However, large companies like IBM and Google are implementing new information technologies to reap surprising as the fact predictions of songs that will be a success, based on information from the websites of Music at the University . There is also debate about whether the driving force of Web 3.0 it will be the artificial intelligence and other systems of human intelligence through collaborative services like Delicious, Flickr and Digg, which draw the order of the network and how people interact with it. Time

now approach the concept of Semantic Web. Thanks to artificial intelligence, can we develop programs that can reason based on description logic and intelligent agents. Such applications can perform logical reasoning using rules that express logical relationships between concepts and data in the network . These changes also allow use on different devices or mobile devices accessible to people with disabilities, or with different languages \u200b\u200bwithout transforming the data. Thus, we will be faced with a semantic evolution in the network.

Finally, another possible path for Web 3.0 is the direction in 3D vision. This would involve transforming the Web into a series of 3D spaces, taking further the concept proposed by the virtual world Second Life . This could open new ways to connect and collaborate, using three-dimensional spaces.

Wednesday, April 7, 2010

Which Indian Acctress Have Bigest Boobs

CENSURES

.


On Saturday April 3 was censured and asked to be silent at a meeting of Aperat (Peruvian Association atheists). Conduct more typical of dogmatic than rational people.
I was questioning the reasons or lack of reasons for a member to his atheism.
When I went to add a critique of the free or emotional way of being an atheist I was interrupted by Aperat president, Manuel Paz y Miño, which prevented me from continuing, I said that these discrepancies or criticism of other members thought the idea was not at that meeting. And I suggested that I shut up. Other attendees, among whom was Rafael Ocaña, were quite pleased with this censorship, an intolerant bone and anti criticism.
Once I saw that he could hear but not speak I retired and all continued their polite meeting of atheists.
To me censorship is nothing new and certainly there will be more incidents like this, if I keep doing things right in a society where the rule is to things wrong.

"Some years ago I was censored and banned from lecturing in the faculty of biology at San Marcos that had a public debate with the chaplain of San Marcos on the human embryo. Edma Professor Maita, then I blame high authority at the end of the debate and I cancel my next presentation. Has stopped talking again formally at my alma mater.
- A few months ago Mr. Julio Rivera, a leader of the Cenacle JachayWiñay philosophical and creator of a new national anthem, I invite you to attend meetings again philosophical home. He said I could not that week but if the other and told me that that's not that expose Quelopana Flores, Bone said I could go to the Upper Room every day that was not exposing Quelopana. Obviously this kind of invitation to take it as an insult.

-At a conference of British philosophy in the Miraflores was literally kicked out by the public for disagreeing with the speaker to let go a number of false and inconsistent reasoning.

Common to these events is to prevent a rational analysis ruin their beliefs. Cover the opening
someone, do not listen. In order to keep believing their lies. What makes
Paz y Miño ie the Aperat wish atheists disbelieve. We do not believe and any reason or revision of this belief is heresy. That is to say that atheism is a dogma of faith, belief and more.

are not really atheists.

price if I be an atheist, and not afraid to examine or doubt my atheism as often as necessary. My atheism is not a decision but a finding. I am pleased to have met some new friends I hope to continue keeping Aperat now that this new Aperat break away from me. Sincerely



Luis Arbaiza

Fastest Remove From Play Deck

WITHOUT WOMEN PLAY ON THE ORIGIN


Tuesday April 6, 2010
How to Convert an egg in sperm? Bibliographic analysis of the epigenetic GAMETES

Blgo. Luis Arbaiza

biologist with a major in genetics Universidad Nacional Mayor de San Marcos.


1 .- INTRODUCTION

A sperm and an egg are genetically identical, which would, theoretically, use of assisted reproduction techniques (especially ICSI, intracytoplasmic injection) for attaining the fertility and biological paternity gametes of the same type (two eggs or two sperm)
But despite their genetic equality, egg and sperm are different epi-genetically.
This epigenetic difference of gametes is called imprinting. Having a maternal and a paternal imprinting.
The union of two gametes, one with other maternal and paternal imprinting allows normal development of the embryo.
The union of gametes with the same imprinting leads to different epigenetic defects and embryonic development unviable. Convert

paternal imprinting in maternal sperm in vitro may permit conversion, epigenetically speaking, a sperm egg, which is perfectly possible biological paternity from the genetic material.

But it is this difference that causes epigenetic? Even
can not completely answer this question.
The motivation of this research is to discover literature.

2 .- WHAT IS THE IMPRINTING?
A gene can be turned on or off. There are a number of
genes that are turned on and off the sperm into eggs. These genes are involved in imprinting.
Thus, eggs and sperm have the same genes but they are active in them. And this makes them functionally different.
The on or off which gives rise to male or female imprinting is a specific and consistent pattern that occurs in gametogenesis.
many and which genes are involved in the imprinting is something that is known only partially. JUSTIFICATION


1 .- The genetic imprint is required for normal development of embryos
This is done in the germ line
The error must carry errors that prevent the successful development of embryos.
Especially in those procedures like ICSI epignéticos processes that accelerate the male gamete.
has been shown greater percentage of epigenetic disease patient
ICSI children have been encontradon defects in the methylation of H19 and MEST IN OLIGOZOSPERMICOS (CJ Marques 2008) This may explain the appearance of the Silver-Russell syndrome in children born with H19 hypomethylation ART. (CJ Marques 2008) also
low unmethylation of the CTCF-binding site Could lead to inactivation of the paternal IGF2 gene, and Be Linked to Decreased embryo quality and birth weight, Often associated with ART. (CJ Marques 2008)
2 .- Imrpinting is a limit to cloning because there is no time for proper reprogramming new drugs
3 .- 4 .- engineering epigenetics


3 .- delimitation of the problem
We have brought several questions even without a complete response: 3.1
Which genes are they?
3.2 When you change?
3.3 Who the changes? 3.4
how the changes?
3.5 What is the uncaused cause of imprinting? Is it genetic or epigenetic?
3.6 What is the relationship with the Sry gene which is obviously the only difference between male genome and feminine and oh to be the starting point of this differentiation? MATERIALS AND METHODS


literature was analyzed in subjects related to try to answer the research questions
For what is agreed to virtual libraries
And software data management. RESULTS


BIBLIOGRAPHIC ANALYSIS QUESTIONS

3.1 WHAT ARE THE GENES? GENES INVOLVED IN IMPRINTING
genome imprinting There are about 156 possible new genes, and imprinting status-gene can be predicted by its sequence (Luedi, PP et al. (2007). The classic mechanism of genetic imprinting of a gene is methylation but not the only and does not necessarily mean inactivation.
Here is a list of some genes known as imprinting involved in the human. Chromosome location
GEN
State sperm into the egg activator State
1 NOEY2
function active (tumor suppressor)
active IGF2 Independent control of others, the change carries many more
7p12 genes (GRB10) in growth factor receptor protein 10
7 q21 PEG10 active inactivated may be a new gene imprinting


7q31.3 MEST isoforms 1 and 2, 8 KCNK9
(active in the brain causes cancer, bipolar and epilepcia)
DLGAP2 8p23 (possible Bladder tumor suppressor)
DLGAP2
associated protein-2 (Dlgap2). WAS
Excluded as the gene responsible for EPMR.
11
inactive H19 noncoding RNA active role in cancer

a member of the AP2 transcription factor family transcription factor E2F1


uan
may control differently from the other
His other genes change more
drag
11 p57, CDKN1C Kip2 active
MEG3
14 q, 15 q11-q13
active SNRPN (small nuclear ribonucleoprotein, polypeptide N) 15 q11-q13
IPW functions not
polypeptide RNA. Predominantly in brain

15 Causes UBE3A Angelman syndrome. on the mother's chromosome Possible 19q13.4

master key active XIST
inactive X
Idica that methylation is removed in spermatogenesis Xist (is in mice)

NESP55
ATP10A
PHLDA2
NDN
MAGEL2
inactive SNRPN
PEG3

KCNQ1OT1
KCNQ1 TP73
CDKN1C
IGF2R
WT1
SLC22A18




3.2 What HAPPENS WHEN IMPRINTING?

During the development of primordial germ cells the pattern of imprinting is erased. Likely to enter the gonad.
in spermatogenesis is completed in the haploid phase (meiosis) in man meiosis occurs before the father as soon as when spermatogonia proliferate, according to some authors is intrinsic and cell-Autonomous.
oogenesis in the imprinting occurs in ocytes and around the time of the first meiotic division, the methylation in women occurs in postnatal development when ooccitos are diplotene prophase I, the maternal imprinting continuously established in the maturation of oocytes .
But methylation may be at different times for different genes (Paolini 2004)
has been found not to be due to the influence of somatic cells of the genital ridge or gonad environment in primary cells. (Paolini 2004) SPERMATOGENESIS


Time
STAGE TIME OF IMPRINTING PHOTO ESATDO


0 Zygote is exaggerated DIFERENCAI
imprinting paternal methylation demethylated shortly after fertilization, and the mother suffers
novo methylation of 4 hours
pronucleus in mouse father is demethylated within 4 hours after fertilization

4 hours

A global demethylation occurs in the morula at 4 h of fertilization. 5 days



reestablished in the blastocyst inner cell methylation in mass but not in the trophectoderm. In the blastocyst reestablesce methylation in the inner cell mass but not in the trophectoderm. (Kierszenbaum AL. 2002)


Primordial germ cells 3-4 weeks as PGCs have migrated paternal and maternal imprinting The Primordial germ cells inherit a biallelic imprinting father and mother, and delete your imprinting to start a de novo during gametogenesis. (Kierszenbaum AL. 2002)
primordial germ cells expressing these genes: Blimp1, Oct3 / 4, Fragilis, Stella, c-Kit, MVH, DAZL and Gcna1 (Deshira Saiti 2000)


H19 and Igf2 are expressed in endoderm and mesoderm (Andrea L. Webber January 1998)

6 weeks Embrionic
germ cells have no imprinting or is deregulated, and gonad are primordial cells

40 are intended to be induced gonad Exra-embryonic tissues that are hypothesized to repress cell
Blimp1 somatization program (or Prdm1), a repressor that foundation helps tarscripcion (Yasuhide Ohinata 2005)

at birth and in some months parental imprinting is completed puberty Start esperamatogenesis
. The paternalisacion is an ongoing process in-Dividing mitotically and meiotically spermatogonial stem cell-derived progeny Dividing spermatocyte (Kierszenbaum AL. 2002)

Dnmt3L and Dnmt3b interact with Dnmt2a and Dnmt3b and is required for proper spermatogenesis. (Kierszenbaum AL. 2002)

The imprinting is already mature in the stem cell line in germinal (CJ Marques 2008)

Spermatogonia are immature germ cells do mitosis
Some differ to primary spermatocytes.
After the first meiosis spermatocytes become secondary
2

These are meiosis 2 and form 2 spermatids





Spermatogonia (diploid) are in speramtozoides already methylated H19

THE AMENDING 3.4 Who?

to imprint genes are usually methylated in its promoter (methylation is the addition of a methyl group on a Carbon nucleotide)



promoters are rich in CpG islands
5-methylcytosine occurs at reacting DNA methyltransferases (DNMT 1, 3a or 3b), which catalyzes the transfer of a methyl group (CH3) from S-adenosylmethionine (SAM) carbon 5 of cytosine methylated
These islands are susceptible to bind to proteins (eg MECP2 "methyl CpG-binding protein 2)
Dnmt3a and Dnmt3b are de novo methylation Dnmt1
when divided by a new DNA methylation in the daughter strand
The demethylation occurs in the absence of Dnmt1 with rounds of DNA replication Continued (passive demethylation), as Actively as well (without DNA replication). The nature of demethyl is unknown.
Dnmt3L assists de novo methylation
Between 60 and 90% of methylated CpG (rare those imprintin few)
Methylation make DNMT1, DNMT3A, DNMT3B Dnmt3a and Dnmt3b appear to be the giving patterns of methylation in the early embryo
DNMT1 is what keeps this pattern of mother cell to daughter (two copies)
methylation is not always
silencing is methylation changes chromatin structure
A pattern of methylation is the result of: 1 .-
de novo methylation maintenance

2 .- 3 .- demethylation
(Paolini 2004)
generally expressed genes in the imprinting raise parental fetal development while it limits the maternal.
(Paolini 2004)
MASH2 regulates the development of spongiotrophoblast
Igf2 has been found in ASCL2
labyrinthine trophoblast is expressed in spongiotrophoblast and labyrinthine

3.5 What is the uncaused cause imprinting?
KCNQ1OT1 The expression of the gene on chromosome 11p15.5, is essential for the imprinting of certain regions. The mechanism may be a gene is active in a ovarian or spermatic say this cascade occurs in other imprinting genes.
studying their transcricion factors could be achieved by knowing what the root causes of IGF2 imprinting


19q13.4
H19 IGF2 H19


19q13.4
The ergenic germline-derived differentially methylated region (IG-DMR) ES CANDIDATOPARA REGION CONTROL OF CHROMOSOME 12
is a cluster that contains: Paternally
Expressed protein-coding genes Dlk1 and DIO3 and several non-coding RNAs, including maternal expression of Gtl2 and C / D snoRNAs.
A retrotransposon-like gene (Rtl1) is Expressed from the paternal chromosome and has an antisense transcript from the maternal Expressed chromosome containing two microRNAs with full Complementarity to Rtl1

Deletion of IG-DMR of the maternal chromosome causes loss of imprinting in all cluster genes
The deletion leaves intact the parental imprinting
Some women do not have a piece of chromosome, 19q13.4 and its imprinting pattern in their eggs is paternal

EXPERIMENT 2 MOTHERS

The zygote genome did so with mature and an immature (Tomohiro Kono 2004) The oocyte was not developed a mouse mutant with a deletion of 13-kilobase
The maternal methylation occurs on oocyte maturation is
The undeveloped (ng)
and development (fg)
But in the ng was not altered Igf2 H19 and H19
To block ng was used in a mouse with a deletion in the gene
The embryos were born to 17.5 days
was confirmed that these embryos do not spend the day 17.5
The 2 were born with retarded growth an underdeveloped liver Igf2 and H19
As Dlk1 and Gtl2 are printed on spermatogenesis. Modification


IMPRINTING synthetic estrogen, diethylstilbestrol (DES) dog developmentally imprint genes by Changing the pattern of DNA methylation. (John A. McLachlan, 2001)
The exreecion of imprinted genes and fetal development is influenced by the addition of fetal calf serum culture medium (Paolini 2004)
not known how this environment affects imprinting Maybe
removes methyl groups, leading to incomplete or clear the pattern of imprinting. (Paolini 2004)


E IMPRINTING
ICSI ICSI Children weigh less (Paolini 2004)

EXPERIMENT
First female sperm stem cells turned into sperm that impregnated
(Nayernia K 2006)
marrow cells were transformed into cells There was an expression of male germ stem cells markers (Nayernia K. 2007)
born mouse had defects and will use special chemicals and vitamins
PRODUCER OF SPERM WOMAN

A molas locus 19q13.4. Examined the methylation in the daughters and the mola
They used the two bisulfite-based Methods (¿??)
The mutation is inherited from the grandfather or maternal grandfather so we conclude that the error was not deleted due to the imprinting marks if not quite the re-establishment of native brands in oogenesis or in post-cigotic maintenance (El-O Maarri 2003)

DISCUSSION
There are apparently two mechanisms that depend locomotive the imprinting of these mechanisms must be related to the presence or absence of SRY but that relationship is still nebulous.
is known that some methylating enzyme is responsible for imprinting genes, these genes also are rich in CpG islands but because in a gamete are methylated and not in another, still the same question arises how this enzyme known to methylate genes and which are not? And as you know when methylated if a sperm or an egg. Some of these enzymes also signal a different or activates these enzymes

The mechanism may be a gene is active in a ovarian or spermatic say this cascade occurs in other imprinting genes. Another question
that emerges from this analysis is Are there polymorphisms in the imprinting genes?)
abortions should study what ICSI and art to see how they are epigenetically by altering these techniques the normal maturation of imprinting in the gametes. There is already evidence of increased disease epigenetic ARTs cup
Deletion of IG-DMR of the maternal chromosome causes loss of imprinting on all cluster genes that marks it as a locomotive gene imprinting.
The deletion leaves intact the parental imprinting
Some women do not have a piece of chromosome: 19q13.4
This healthy gene feminizaría eggs.
sperm could feminize H19 and Igf2, apparently, are printed by a mechanism independent of this.
Achieving the correct expression of IGF2 and ha19 a large number of other genes is well placed (maternal bone becomes father)
The experiment of mice with two mothers can deduce the following: "You can

concluded that an immature oocyte and sperm except for 2 genes (IGF2 and H19)
-one was nullified (h19) to get the sperm
-hence a sperm and an egg is immature except for 2 genes
- If you add the egg maturation factors and vanishes IGF2 could turn sperm into eggs.

weigh less ivf Apparently, that talks about winning the maternal genes that bone paternal genes are incomplete
WOMEN PRODUCERS MDE SPERM
If there is a mutation that makes the maternal genome paternal
1 .- A simple element determines parenthood
genome that gene 2.-feminizaría healthy sperm. 3 .- partenisación
genome requires no activation or suppression of this gene or factor.
The normal state is paternal
may first have to delete and then print
We hypothesize that the factor of follicular development as well as IGF2 gene silencing can change the parental imprinting of the sperm mother


CONCLUSION Two mechanisms start the cascade of events leading to the pattern of paternal or maternal imprinting.
A gene in 19q13.4 is responsible for feminizaría a significant number of genes to print
And another alter H19 and Igf2
Thanks


BIBLIOGRAPHY

l1 Arie Look, Edward Robinson2, John R. McCarrey2 & Howard Correlates Gamete-specific methylation with imprinting of the murine Xist gene Nature Genetics 9, 312 to 315 (1995) Mira Arie

l1, Edward Robinson2, John R. McCarrey2 & Howard Cedar1 Correlates Gamete-specific methylation with imprinting of the murine Xist gene Nature Genetics 9, 312 to 315 (1995)

CV Beechey IMPRINTING GENETIC AND PHYSICAL MAP OF THE MOUSE
and B.M. Cattanach Mammalian Genetics Unit, Harwell, Didcot, Oxon OX11 ORD, UK

El-Maarri O, Seoud M, Coullin P, Herbiniaux U, Oldenburg J, Rouleau G, Slim R Maternal alleles acquiring paternal methylation patterns in biparental complete hydatidiform moles Hum Mol Genet 2003; 12:1405-13
2003

El-Maarri O, Slim R Familial hydatidiform molar pregnancy: the germline imprinting defect hypothesis? Curr Top Microbiol Immunol 2006; 301:229-41 2006

Horsthemke, B Gerald F. Bai-Lin Wu,1,2 and Bernhard Horsthemke5Charité, Am J Hum Genet. 2002 July; 71(1): 162–164. Intracytoplasmic Sperm Injection May Increase the Risk of Imprinting Defects

Kaomei Guan1,4, Karim Nayernia2,4, Lars S. Maier1, Stefan Wagner1, Ralf Dressel3, Jae Ho Lee2, Jessica Nolte2, Frieder Wolf1, Manyu Li2, Wolfgang Engel2 & Gerd Hasenfuss Pluripotency of spermatogonial stem cells from adult mouse testis Nature 440, 1199-1203 (27 April 2006) 2006

Kierszenbaum AL. Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths. 2002
Mol Reprod Dev. 2002 Nov;63(3):269-72.

Lin SP, Youngson N, Takada S, Seitz H, Reik W, Paulsen M, Cavaille J, Ferguson-Smith AC. Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. 2003Nat Genet. 2003 Sep;35(1):11-2.

Luedi, P.P et al. Computational and experimental identification of novel human imprinted genes. (2007) Genome Res 17:1723-1730].
Manning Martina a, Willy Lissensb, Wolfgang Weidnera, Inge Liebaersb DNA Methylation Analysis in Immature Testicular Sperm Cells at Different Developmental Stages
Vol. 67, No. 2, 2001
MANNING Martina; LISSENS Willy ; LIEBAERS Inge ; VAN STEIR TEGHEM André ; WEIDNER Wolfgang ; Imprinting analysis in spermatozoa prepared for intracytoplasmic sperm injection (ICSI) International journal of andrology
2001, vol. 24, no2, pp. 87-94 (17 ref.)

McLachlan John A. , Mathew Burow, Tung-Chin Chiang and Shaun Fang Li
Gene imprinting in developmental toxicology: a possible interface between physiology and pathology 2001 Toxicology Letters
Volume 120, Issues 1-3, 31 March 2001, Pages 161-164

Marques C.J. 1, P. Costa1, B. Vaz1, F. Carvalho1, S. Fernandes1, A. Barros1,2 and M. Sousa Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia2008 Molecular Human Reproduction 2008 14(2):67-74;

Nayernia K. Drusenheimer N, Wulf G, Nolte J, Lee JH, Dev A, Dressel R, Gromoll J, Schmidtke J, Engel W, Putative human male germ cells from bone marrow stem cells. Soc Reprod Fertil Suppl. 2007;63:69-76.

Nayernia K., Lee J.H., Drusenheimer N., Nolte J., Wulf G., Schwandt I., Ralf D., Müller C.H., Gromoll J., Engel W. Derivation of germ cells from bone marrow stem cells. Lab Invest Volume: 86 Pagination: 654-6632006

Nayernia K, Vauti F, Meinhardt A, Cadenas C, Schweyer S, Meyer BI, Schwandt I, Chowdhury K, Engel W, Arnold HH. Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility.
J Biol Chem. 2003 Nov 28;278(48):48377-85. Epub 2003 Sep 16.

Nayernia K.Lee J.H., Engel W., Stem Cell Protein Piwil2 Modulates Expression of Murine Spermatogonial Stem Cell Specific Genes.
Mol Reprod Dev. Volume: 73 Number: 2 Pagination: 173-1792006

Nayernia K, Nolte J, Michelmann HW, Lee JH, Rathsack K, Drusenheimer N, Dev A, Wulf G, Ehrmann IE, Elliott DJ, Okpanyi V, Zechner U, Haaf T, Meinhardt A, Engel W.In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice. Dev Cell. 2006 Jul;11(1):125-32

Nayernia K, Lee JH, Drusenheimer N, Nolte J, Wulf G, Dressel R, Gromoll J, Engel W.Derivation of male germ cells from bone marrow stem cells.
Lab Invest. 2006 Jul;86(7):654-63. Epub 2006 May 1.

Paoloni Ariane -Giacobino1 and J Richard Chaillet Genomic imprinting and assisted reproduction Reprod Health v.1; 2004


Saiti Deshira and Orly Lacham-Kaplan Mouse Germ Cell Development in-vivo and in-vitro Tomohiro Kono1,3, Yayoi Obata1,3,
Quiong Wu1,3, Katsutoshi Niwa1,3,Yukiko Ono1, Yuji Yamamoto2,3, Eun
Sung Park4, Jeong-Sun Seo4,5& Hidehiko Ogawa1,3 Birth of parthenogenetic mice that can develop to adulthood2004 NATURE (14 July
2005)


Treatment Of Stone At Uv Junction

TIME, RAYMUNDO TALKS WITH THE BIOCHEMICAL PROPERTIES

ON THE ORIGIN OF TIME TALKS WITH HOUSE RAYMUNDO


Dear Raymond, think you have to dissect the problem is the parts to see if they are less arduous.
1. The problem of the universe and that there is not nothing. The problem is current and not necessarily before the threshold of plank.
note that there is a universe. What I am saying only one explanation I think is a reflection or a perplexity on the scare of his life.
The universe is possible. Proof of this is that it is. (It would be absurd that the universe is impossible and yet it were).
Then we have that the universe is possible. It is not absurd or inconsistent that I had.
Now imagine that the universe had not (the question that there is a universe and not only alludes to believe may not be any), good if there was anything, it would be unusual for having been able to have a universe that did not exist.
imagine anything I think instead of the universe is impossible, (Eye impossible to think not to be) we restricted the limits of our thinking. I think not only should not issue any opinion on the unthinkable, but we can not.

2 .- Another problem is the state of the cosmos before the time of plank. On this at least we had time, the threshold plank is not the beginning of time but a point after a very tiny segment of time.
On the other hand is the inflationary theory, which is the most accepted and so far the most consistent with experimental evidence, in her first time would actually be imaginary time (root of -1) would be not only time back but a projection of time to a lower size.
According to the strings (not yet accepted theory) perhaps there is a plank before the time would not be infinitely divisible and plank time would that limit. An atom or temporal terms. There would be no earlier.

3 .- A third problem is the "before the origin of time." (This is a stage before the threshold of plank) but you can not talk about before temporarily or causally.

Here are two possibilities, one that can be a being or something without time or space. Then the universe could be in a timeless state only a "change of status" would realize their "origin" U
another possibility is that this is not possible.
I think that since the three-dimensional objects have an edge and are finite, but aya which are no longer an object of 4 dimensions (time) is also finite and can have an edge and that is the origin of the universe and the other end. Strange, difficult to conceive that there was anything serious infinite


When I referred to other universes, universes born I was referring rather to the multiple universe theories as scientific hypotheses rather than the old idea of \u200b\u200ba universe will tell and expands.
On this there is a beautiful article. Proof of the nature of scientific vagary. Helene et Le Meur
Daninos Franck. Notre Univers est-il unique? 1.Les Scenarios Paralleles des Mondes. 2. Quatre formes multiverse. 3.Dieu-il avait le choix in Creant l'Univers?. 4. Aurelien Barrau: Les Lois de Physique Menent aux the multiverse? The Recherche Setembre 2009 No 433 pp 38-53


4 .- The problem of the laws of the universe. It is good the distinction made by thermodynamic chaos chaos as the absence of laws. I think that is why there are laws in nature and this happens not just in chaos. Another problem is that if such a universe would be chaotic. Or that in the course of history of the universe this way a period of no laws to other laws.
On this I think all we know is that after there are laws plank. Before we know whether or not there. We can not say his absence or lack, just stop any trial. 5 .-


the existence of god, this is another problem too.
I do not think as Bertrand Russell, what to refute deism deism claim that those who believe. Whoever claims to support. If I said that descend directly from Nailamp, nobody could deny. But to accept that it is true that I depend on proof that nobody can deny.
do not think the existence of laws that Deimos discuss possible natural laws are not regulations, but findings.
If I see a stone that encounter on the road is green. I can not think that the fact that color means that someone has painted it and gave it the color. I accept that a stone should have some property. Natural laws are characteristic of being in the universe. It is impossible not to take them.

addition, some laws such as thermodynamics seem to be possible otherwise to be what they are. The laws of evolution may not be either. In the sense that given the inertia of matter, its lack of will, is expected to occur as is happening, and thus account for the majority of natural laws. Here the problem is that the universe is so coherent and absurd.
Here the matter is split into more trouble, perhaps we have evolved to understand the universe, and not that the universe is coherent in itself.
Even more, here is the problem that anyone could believe possible an absurd universe. In this case I think is something you can say but not thinking. And if I could be a universe. We could not examine it. or meditate on it. So we're trapped somehow restricted to the limits of coherent and indispensable. We do not know if the universe or just fit there.

6 .- Finally on my book, sorry to disappoint, it contains no argument against theism. Simply ignores God. There is a god because I believe that there is no reason to suppose. From what I know not of any book that has strong arguments in favor of theism. (If you have or there, an atheist would be an act of stubbornness or ignorance)

what I propose to continue (if continuous) of this nice chat dissenting, a couple of rules of conversation.
1 .- argue and do not qualify (can be called without argument, for example say that 1 +1 = 2 or E = MC2 are stupid and false ideas)
2 .- To adhere to written or said (not considered contained in the another, it is impossible to talk if the other would put words in his mouth to one.)
These things have landed among us, but not over anticipate and recommend to other meditators in this fascinating subject. Greetings


Lucho,

laberintum ile A typical mundum, sed redeuti Largus intranti nimius artus.
(The world is like a labyrinth, it seems too big to enter, too young to go.)


Dear Raymond.

understand that the two reasons plausible that you created the idea of \u200b\u200bGod are: 1 .-
the universe is full of symmetries, a phrase that reminds me of Einstein, who said the most incomprehensible of the universe is that it is understandable. Meaning
astonishment or perplexity that there is order in the universe. But say, if the nervous systems evolved in the universe as a means of adaptation to the environment, it is normal that we can understand.
On the other hand is a very beautiful sentence, I can not remember the author, an epistemologist that if, read:
science is to explain the complexity of the visible through the simplicity of the visible. Simplex veri sigillum ["Simplicity is the hallmark of truth"]
Well, apparently the natural laws of the universe are simple attributes that bear fruit with very complex interacting phenomena. Well

. This only allows us to be so surprised. The universe has laws. But it has to do with god. Why it is necessary for you god because of there natural laws? As I said before these laws are conventions or decisions (with the author or authors as human laws), but findings, to be expressions of the cosmos. There is another difference, human laws may be violated, we must strive to perform or an authority must monitor the exercise.
But natural law is inviolable, no one could testify that they accurately violated.

As a third difference, human laws are artificial and natural, well, are natural
From this we can deduce that if you believe that there are laws which alludes to the existence of a legislator is abusing the scope of an analogy. The word, laws have different meanings in the case of human or natural. As a legislator could have and others do not.

These laws rather than properties of the universe are the same universe. That somehow has to be. I see no need for god to exist natural laws. Moreover, the miracles are violations of natural law. So the finding that natural laws are inviolable in the world observed nowadays contradicts the existence of miracles or supernatural phenomena. As necessary to perform miracles in God, then the laws of God rather than speak deny it,

2 .- the anthropic principle
The existence of the universe allow the existence of man, not necessarily just possibly.
here the cause is the universe and its consequence (not required) is the man
not reverse the causal order we think that man is causing the universe to be like. And anyway, what's wonderful about the man that his existence is proof of a divine will?
If we see an oxide formed on a metal bar old should not think that the iron had the will to exist to produce oxide The oxide was simply
. Finally

disagreement with someone as smart and prepared as you always a pleasure and an enriching experience, I congratulate an opponent on your level. I ask permission to reproduce part of our conversation on my blog.
Sincerely, Lucho


Dear Luis, again express their views seem pretty reasonable and do not really think I can refute them. In fact, I am not a Deist, but I keep deism sympathy to the extent that has a strong heuristic: allows advance knowledge of the universe. If I throw the dice and get two six, and this is repeated 66 times, if there is no trick, worthy of awe, very difficult to explain by chance. However, it can be said as Democritus argued that everything is governed by chance and necessity. However, the theistic hypothesis states that the abundant symmetries of the universe can be explained in terms of a very thin, as if the universe were a computer. If you have a single principle that can explain the whole cosmos (so-called theories of everything that both dazzle Hawking), I do not think deism is tested, but quite plausible, it could not refuse like a stupidity.

I, Lucho, do you consider worthy of discussion only the weak anthropic principle, and not strong. Some argue that the strong principle is a tautology. I think it is a metaphysical idea (in the sense of Popper) that has tremendous heuristic value. I only say that (I think I approach each Kiko) well taken deism can do more for science than atheism that trashy, conceited, despises all search which starts from the dogma of non-belief.

Sincerely, Raymundo Casas